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Therapeutic indications include the delivery of local anesthetics for pain relief and the delivery of corticosteroids for suppression of inflammation. [1] In addition, it is the initial treatment for the neurogenic dyshidrosis. [2] L-Cyclobenzamide, which was developed as a treatment agent for neurogenic dyshidrosis and subsequently marketed as Dactinomycetin, was first evaluated in an Italian trial where it was found that it was superior to placebo for pain. [3] Similar to a combination of theophylline and an anti-inflammatory drug, L-Cyclobenzamide was found to be effective as an augmentation agent. [4] Further studies revealed that a combination of both L-Cyclobenzamide and an anti-inflammatory agent worked better than either a combination of analgesics alone. [5] In addition to that, the combination of L-Cyclobenzamide and an anti-inflammatory agent could be beneficial in patients in need of adjuvant therapy due to their underlying neurogenic dyshidrosis. [6] With that said, these results suggest L-Cyclobenzamide could be useful in the management of neurogenic dyshidrosis due to its anti-inflammatory, anti-gastric, and neurogenic properties and its ability to work in combination with theophylline. [7] Cyclobenzamide as a general analgesic with anti-inflammatory properties was also first evaluated. Cyclobenzamide was shown to be effective in reducing the pain of diabetic peripheral neuropathy. [8] With that said, other studies are still ongoing and additional trials will be done to further evaluate Cyclobenzamide as a potential agent for neurogenic dyshidrosis. Cyclobenzamide was also tested as an addition to proton pump inhibitors in various brain tumor models of multiple sclerosis. [9] While it was found that Cyclobenzamide was effective in reducing neuropathy in multiple sclerosis models by enhancing motor and somastic responses of the CNS due to both the induction of the proton pump inhibition pathway as well as an increase in the expression of neurotrophin tyrosine phosphorylation (NTRP3) and the production of nitric oxide, it did not have any impact on the proliferation of tumors. [10] Overall, Cyclobenzamide appears to be a promising agent. It has a relatively low toxicity compared to other anti-inflammatory agents. It has been well-studied since its introduction and has shown to have a good safety profile. Its potential role in neurogenic dyshidrosis has Related Article:

Deca 6.0 lpf medidas, dog steroids for sale
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